Escape Velocity

Escape Velocity: Why the Prospect of Extreme Human Life Extension Matters Now

The biogerontologist David Sinclair and the bioethicist Leon Kass recently locked horns in a radio debate on human life extension that was remarkable for one thing: on the key issue, Kass was right and Sinclair wrong. Sinclair suggested, as have other experts, including his mentor Lenny Guarente and the National Institute on Aging advisory council member Elizabeth Blackburn, that Kass and other bioconservatives are creating a false alarm about life extension, because only a modest (say,30%) increase in human life span is achievable by biomedical intervention,whereas Kass’s apprehensions concern extreme or indefinite life extension.

The foresseability of real anti-aging medicine


Anti-aging medicine does not yet exist, in the sense in which the term “medicine” is generally used. Effective medicine nearly or completely eliminates the risk of death from its target cause; antibiotics, for example, have cut American deaths from bacterial infections by a factor of 20 in the past century. All we have to combat aging, at this point, is interventions that modestly (if at all) delay the onset and progression of age-related frailty. In the past few years, however, it has become possible to enumerate a comprehensive panel of technically feasible interventions, which, jointly, would probably constitute real anti-aging medicine: that is, would probably reduce the risk of death from current age-related causes to a level similar to our present risk of death from bacterial infections. The timeframe for developing these interventions in laboratory mice has recently been authoritatively estimated to be around a decade from now. We don’t know how long it would take thereafter to translate them to humans, but it might only be a couple of decades. As the population aged while in possession of these medicines, new aspects of aging would doubtless emerge that would need progressively more sophisticated medicine, but these might well not be beyond us once aging’s aura of immutability has at last been swept aside.